This multi-disciplinary research programme will develop novel material solutions for use in advanced wound healing based on nanofibrillated cellulose structures. This proposal requires knowledge on the effective production and application of sustainable and innovative micro- and nanofibres based on cellulose. The project will assess the ability of these nanofibres to interact with complementary polymers to form novel material structures with optimised adhesion and moulding properties, absorbance, porosity and mechanical performance. The NanoHeal proposal brings together leading scientists in the fields of nanocellulose technology, polymer chemistry, printing and nanomedicine, to produce biocompatible and biodegradable natural polymers that can be functionalized for clinical applications. As a prototype model, the project will develop materials for use in wound healing. However, the envisaged technologies of synthesis and functionalization will have a diversity of commercial and industrial applications.
The project is funded by the Research Council of Norway/NANO2021 (grant no. 219733), and is a cooperation between several leading R&D partners.
- NTNU, Faculty of medicine
- Cardiff University
- Swansea University
- Lund University
Project period: 2012-2016.
Project manager: Gary Chinga Carrasco.
Adam Rees, Swansea Univeristy is engaged as a PhD student in the NanoHeal project. He will be working with functionalization of nanocellulose film surfaces.
MSc Heriette Rogstad is engaged as PhD student and will be working with assessment of nanocellulose biomaterials for wound healing.
140604: Project meeting. Cardiff University, Dental School. Cardiff, UK.
131209: Project meeting. NTNU, Institute of Cancer Research and Molecular medicine. Trondheim.
130529: Project meeting, Lund, Sweden.
120925: Kick-off meeting, PFI, Norway.
Photo Taken at the Gastrosenteret, St Olav hospital. Trondheim
Three-dimensional visualization and quantification of structural fibres for biomedical applications. Invited book chapter contribution, in: "Confocal Laser Microscopy", ISBN 980-953-307-966-5.
Published articles in Web of science (ISI) :
"Three-Dimensional Microstructural Properties of Nanofibrillated Cellulose Films". Int. J. Mol. Sci. 2014, 15(4), 6423-6440.
"Pretreatment-dependent surface chemistry of wood nanocellulose for pH-sensitive hydrogels". J. Biomaterials Applications, 2014, In press.
"The effect of residual fibres on the micro-topography of cellulose nanopaper". Micron, 2014, 56: 80-84.
"Management of wound infections with dressing manufactured from nanocellulose fibers derived from Pinus radiata wood pulp". Wound repair and regeneration, 2013, 21(6): A79-A79.
NanoHeal in electronic media
140414: "Preparing nanocellulose for eventual use in dressings for wounds". frogheart.ca
140410: "Surface-modified nanocellulose hydrogels for wound dressing". NanoWerk
140116: "Nanocellulose-based wound dressings". Focus on, PFI.
130527: The Science Museum, London.
120828: "Research project funded for wound healing using nanocellulose". BioBasedDigest.
120823: "Bio-compatible cellulose nanostructures for advanced wound healing applications". Nanowerk.
140326: Immunogenic properties of TEMPO-treated wood nanocellulose. BioNanoMed Conference- Nanomaterials for Biomedical Applications, March 26 – 28, Krems, Austria.
140120: "Nanocellulose from wood as a biomaterial for biomedical applications". Invited talk, ISN2A - Int. symposium on nanoparticles/nanomaterials and applications, 20-22, Lisbon, Portugal.
131023: "Biocompatibility of nanocellulose". Innventia days, 22-23 October, Stockholm, Sweden.
131023: "Towards the management of wound infections with dressings manufactured from nanocellulose derived from Pinus radiata wood pulp". 23rd European Tissue Repair Society Meeting. Stem cells and regenerative medicine. 23-25 October. Reims, France.
131021: "Controlling the elastic modulus of nano-engineered hydrogels by crosslinking cellulose nanofibrils". EPNOE 2013: "Polysaccharides and polysaccharide-derived products, from basic science to applications. 21st -24th October. Nice, France.
130313: "Designing nanocellulose qualities for wound dressings". BioNanoMed2013. 4th international congress, Nanotechnology, Medicince, Biology. 14-15 March, Krems, Austria.
121204: "The potential of cellulose nanofibrils from wood pulp fibers as a substrate for wound healing applications". Workshop. Understanding wood cell wall structure, biopolymer interaction and composition: implications for current products and new material innovation. Stockholm, Sweeden.
121121: "Potential cellulose-based materials for wound healing applications". Treforedlingsforum, Oslo, Norway.