The Interaction of Wood Nanocellulose Dressings and the Wound Pathogen P. aeruginosa

Updated: 2016-12-19 | Print

Alison A. Jacka, Henriette R. Nordlib, Lydia C. Powella,  Kate A. Powella,  Himanshu KishnaniaPer Olav Johnsenc, Brita Pukstadb,d,  David W. Thomasa, Gary Chinga-Carrascoc, Katja E. Hilla

a Advanced Therapies Group, Oral and Biomedical Sciences, Cardiff University School of Dentistry, Cardiff, CF14 4XY, UK
b Department of Cancer Research and Molecular Medicine, NTNU, Trondheim, Norway
c PFI, Høgskoleringen 6b, NO-7491 Trondheim, Norway
d Department of Dermatology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway

Chronic wounds pose an increasingly significant worldwide economic burden (over £1 billion per annum in the UK alone).  With the escalation in global obesity and diabetes, chronic wounds will increasingly be a significant cause of morbidity and mortality.  Cellulose nanofibrils (CNF) are highly versatile and can be tailored with specific physical properties to produce an assortment of three-dimensional structures (hydrogels, aerogels or films), for subsequent utilization as wound dressing materials.  Growth curves using CNF (diameter <20 nm) in suspension demonstrated an interesting dose-dependent inhibition of bacterial growth.  In addition, analysis of biofilm formation (Pseudomonas aeruginosa PAO1) on nanocellulose aerogels (20 g/m2) revealed significantly less biofilm biomass with decreasing aerogel porosity and surface roughness.  Importantly, virulence factor production by P. aeruginosa in the presence of nanocellulose materials, quantified for the first time, was unaffected (p>0.05) over 24 h.  These data demonstrate the potential of nanocellulose materials in the development of novel dressings that may afford significant clinical potential.

Carbohydrate Polymers 157, 1955–1962